Accelerated enzymatic hydrolysis of biomass (biofuel production) at Københavns Universitet

Lytic Polysaccharide MonoOxygenases (LPMOs) have been shown to greatly increase sugar yields in industrial scale biomass conversion and biofuel production. In laboratory experiments, these enzymes are usually tested on pure cellulose together with energy-rich co-substrates such as vitamin C, oxygen or hydrogen peroxide – all compounds that are shortlived. Unsurprisingly, it has been hard to apply reactions conditions optimized for pure cellulose degradation to dirty biomass degradation, e.g. wheat straw. We have identified some long-lived, naturally occurring compounds that enable LPMO activity, and the aim of this project is to show that these compounds activates LPMO on both pure and dirty substrates. 

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